持续光照剥夺和α-2u-球蛋白替代疗法对大鼠促性腺激素血清浓度和睾丸活性的影响。

Effect of continual light deprivation and alpha-2u-globulin replacement therapy on serum concentration of gonadotropins and testicular activity in rats.

作者信息

Ghosh P K, Biswas R, Mandal H, Biswas N M

机构信息

Department of Physiology, University Colleges of Science and Technology, Calcutta, India.

出版信息

Andrologia. 1996 Nov-Dec;28(6):309-13. doi: 10.1111/j.1439-0272.1996.tb02807.x.

DOI:10.1111/j.1439-0272.1996.tb02807.x

PMID:9021042

Abstract

Prolonged darkness caused a fall in testicular 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity and diminished spermatogenesis, serum levels of gonadotropins, testosterone and alpha 2u-globulin. Administration of alpha 2u-globulin at a dose of 1.5 mg rat-1 per day for 7 days after 68 days of light deprivation, reversed the 17 beta-HSD activity and serum levels of gonadotropins, testosterone and alpha 2u-globulin, while spermatogenesis was restored to normal. The animals kept in prolonged darkness for 68 days and then received saline (7 days in light-dark cycle, 14 L: 10 D), showed no significant changes of testicular activity, serum levels of gonadotropins, testosterone and alpha 2u-globulin, when compared with dark-exposed animals (68 days) receiving rabbit serum (7 days in light-dark cycle, 14 L: 10 D). These results suggest that alpha 2u-globulin plays an important role in testicular function in dark-exposed rats by inducing gonadotropins and testosterone secretion.

摘要

长时间黑暗会导致睾丸17β - 羟基类固醇脱氢酶（17β - HSD）活性下降，精子发生减少，促性腺激素、睾酮和α2u - 球蛋白的血清水平降低。在剥夺光照68天后，每天以1.5毫克/只大鼠的剂量给予α2u - 球蛋白，持续7天，可使17β - HSD活性以及促性腺激素、睾酮和α2u - 球蛋白的血清水平恢复正常，同时精子发生也恢复到正常水平。将动物置于长时间黑暗环境68天，然后给予生理盐水（在明暗循环中7天，14小时光照：10小时黑暗），与接受兔血清（在明暗循环中7天，14小时光照：10小时黑暗）的黑暗暴露动物（68天）相比，睾丸活性、促性腺激素、睾酮和α2u - 球蛋白的血清水平无显著变化。这些结果表明，α2u - 球蛋白通过诱导促性腺激素和睾酮分泌，在黑暗暴露大鼠的睾丸功能中发挥重要作用。