Biswas N M, Ghosh P K, Ghosh K K, Neuhaus O W
J Endocrinol. 1983 Feb;96(2):321-7. doi: 10.1677/joe.0.0960321.
Adult male rats were given injections of oestradiol-17 beta (50 micrograms/100 g body wt per day) for 7 days. When they were killed 14 days after the last injection, serum levels of gonadotrophins and testosterone and weights of accessory sex organs were less, testicular 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity was suppressed and spermatogenesis was inhibited. Administration of alpha 2u-globulin (1.5 mg/day) for 14 days to oestrogen-treated rats and for 10 days to control rats resulted in increased concentrations of gonadotrophins and testosterone in the serum. Accessory sex organ weight and spermatogenesis appeared to be normal while 17 beta-HSD activity increased in oestrogen-treated rats after treatment with alpha 2u-globulin. It was concluded that alpha 2u-globulin has an effect on testicular function in oestrogenized rats by inducing gonadotrophin and testosterone synthesis.
成年雄性大鼠每天注射17β-雌二醇（50微克/100克体重），持续7天。在最后一次注射14天后将它们处死时，促性腺激素和睾酮的血清水平以及附属生殖器官的重量降低，睾丸17β-羟基类固醇脱氢酶（17β-HSD）活性受到抑制，精子发生受到抑制。给经雌激素处理的大鼠注射α2u-球蛋白（1.5毫克/天）14天，给对照大鼠注射10天，导致血清中促性腺激素和睾酮的浓度升高。附属生殖器官重量和精子发生似乎正常，而在用α2u-球蛋白处理后，经雌激素处理的大鼠的17β-HSD活性增加。得出的结论是，α2u-球蛋白通过诱导促性腺激素和睾酮合成，对雌激素化大鼠的睾丸功能有影响。
