Ghosh P K, Biswas N M
Andrologia. 1984 Sep-Oct;16(5):458-64. doi: 10.1111/j.1439-0272.1984.tb00397.x.
Adult male rats were treated with estradiol-17 beta (50 micrograms/100 g body wt./day) for 7 days. When the animals were killed 14 days later, the levels of serum gonadotrophins, testosterone and alpha 2u-Globulin as well as the weight of sex organs were reduced, testicular 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity was also suppressed; spermatogenesis was inhibited. Administration of corticosterone (2 mg/day) for 14 days to estrogen-treated rats increased the concentration of gonadotrophins, testosterone and alpha 2u-globulin in the serum. The weight of accessory sex organs and spermatogenesis appeared to be normal while 17 beta-HSD activity increased in estrogen-treated rats after treatment with corticosterone. It is concluded that corticosterone has an effect on testicular function by inducing alpha 2u-globulin and gonadotrophins in estrogen treated rats.
成年雄性大鼠用17β-雌二醇（50微克/100克体重/天）处理7天。14天后处死动物时，血清促性腺激素、睾酮和α2u-球蛋白水平以及性器官重量降低，睾丸17β-羟类固醇脱氢酶（17β-HSD）活性也受到抑制；精子发生受到抑制。给经雌激素处理的大鼠连续14天给予皮质酮（2毫克/天），可增加血清中促性腺激素、睾酮和α2u-球蛋白的浓度。附属生殖器官的重量和精子发生似乎正常，而经皮质酮处理后，经雌激素处理的大鼠的17β-HSD活性增加。得出的结论是，皮质酮通过在经雌激素处理的大鼠中诱导α2u-球蛋白和促性腺激素对睾丸功能产生影响。
