Longaker M T, Adzick N S, Hall J L, Stair S E, Crombleholme T M, Duncan B W, Bradley S M, Harrison M R, Stern R
Fetal Treatment Program, University of California, San Francisco 94143-0506.
J Pediatr Surg. 1990 Apr;25(4):430-3. doi: 10.1016/0022-3468(90)90387-o.
Fetal wound healing occurs rapidly and without inflammation, fibrosis, or scar formation. It is a process fundamentally different from adult wound healing. The mechanisms that underlie such unique healing properties are unknown. However, hyaluronic acid, a glycosaminoglycan component of the extracellular matrix, is prominent throughout the course of fetal wound healing, and is thought to play a major role in the healing process. Amniotic fluid contains high levels of hyaluronic acid. Amniotic fluid also contains a number of potent growth factors that are critical for fetal development. In this report, a new factor in amniotic fluid that stimulates deposition of hyaluronic acid is described. This activity is measured in an in vitro assay system in which cultured fibrosarcoma cells are used as indicator cells. Amniotic fluid thus provides two separate mechanisms for the deposition of hyaluronic acid. One is by exogenous application directly onto fetal skin wounds; the second is by providing a factor to increase the production of hyaluronic acid endogenously, by stimulating cells around the wound site. The resulting hyaluronic acid-rich area may support the ability of the fetal wound to heal with its unique properties.
胎儿伤口愈合迅速，且无炎症、纤维化或瘢痕形成。这是一个与成人伤口愈合根本不同的过程。导致这种独特愈合特性的机制尚不清楚。然而，透明质酸作为细胞外基质的一种糖胺聚糖成分，在胎儿伤口愈合过程中始终显著存在，并被认为在愈合过程中起主要作用。羊水含有高水平的透明质酸。羊水还含有许多对胎儿发育至关重要的强效生长因子。在本报告中，描述了羊水中一种刺激透明质酸沉积的新因子。这种活性在体外检测系统中进行测量，该系统使用培养的纤维肉瘤细胞作为指示细胞。因此，羊水为透明质酸的沉积提供了两种不同的机制。一种是通过直接外用于胎儿皮肤伤口；第二种是通过提供一种因子来内源性增加透明质酸的产生，即刺激伤口部位周围的细胞。由此产生的富含透明质酸的区域可能支持胎儿伤口以其独特特性进行愈合的能力。
