Govinatzki M T, Velleda L S, Trindade V M, Nagel F M, Bueno D, Perry M L
Departmento de Bioquímica, Universidade Federal de Rio Grande do Sul, Porto Alegre, Brazil.
Neurochem Res. 1997 Jan;22(1):23-6. doi: 10.1023/a:1027364918315.
We studied protein synthesis, lipid synthesis and CO2 production by oxidation of glycine, alanine and leucine by slices of rat hippocampus during the period of brain growth spurt. The metabolism of the three amino acids decreased with the age of the animals. A major reduction was observed in protein synthesis, which was 4 times higher at 7 days of age than at 21 days of age for all amino acids studied. Glycine oxidation to CO2 was twice as high as alanine oxidation and ten times higher than leucine oxidation. The major pathway of leucine utilization was incorporation into proteins. Glycine was the amino acid that had the highest metabolic rate.
我们研究了在脑发育加速期大鼠海马切片对甘氨酸、丙氨酸和亮氨酸的氧化作用，以及由此产生的蛋白质合成、脂质合成和二氧化碳生成情况。这三种氨基酸的代谢随着动物年龄的增长而降低。蛋白质合成出现了显著下降，在所研究的所有氨基酸中，7日龄时的蛋白质合成比21日龄时高4倍。甘氨酸氧化生成二氧化碳的量是丙氨酸氧化的两倍，是亮氨酸氧化的十倍。亮氨酸利用的主要途径是掺入蛋白质中。甘氨酸是代谢率最高的氨基酸。
