Pyne J M, Patterson T L, Kaplan R M, Gillin J C, Koch W L, Grant I
Veterans Affairs Medical Center, Department of Psychiatry, San Diego, CA 92161, USA.
Psychiatr Serv. 1997 Feb;48(2):224-30. doi: 10.1176/ps.48.2.224.
This study examined the relationship between a measure of quality of life and measures of depressive symptoms among patients with major depression.
One hundred patients with primary major depression and 61 control subjects from the San Diego Veterans Affairs Medical Center and surrounding area were compared using a variety of measures, including the Quality of Well-Being (QWB) scale, the Hamilton Rating Scale for Depression, and the Beck Depression Inventory.
After analyses controlled for age, gender, family history of mental illness, and comorbid axis III diagnosis, subjects' scores on the QWB were significantly correlated with their scores on the Hamilton scale and Beck inventory. The severity of depressive symptoms was inversely related to quality of life as measured by the QWB, independent of the variables that were controlled for.
The QWB is sensitive to symptoms of depression among patients diagnosed with major depression. The reduction in quality of life associated with psychiatric symptoms of depression is comparable to that observed among physically ill patients.
本研究探讨了重度抑郁症患者的生活质量指标与抑郁症状指标之间的关系。
使用多种测量方法，包括幸福感量表（QWB）、汉密尔顿抑郁评定量表和贝克抑郁量表，对来自圣地亚哥退伍军人事务医疗中心及周边地区的100例原发性重度抑郁症患者和61例对照受试者进行比较。
在对年龄、性别、精神疾病家族史和共病轴III诊断进行分析控制后，受试者在QWB上的得分与他们在汉密尔顿量表和贝克量表上的得分显著相关。独立于所控制的变量，用QWB测量的抑郁症状严重程度与生活质量呈负相关。
QWB对诊断为重度抑郁症的患者的抑郁症状敏感。与抑郁症精神症状相关的生活质量下降与在身体疾病患者中观察到的情况相当。
