Indinnimeo M, Giarnieri E, Stazi A, Cicchini C, Brozzetti S, Valli C, Carreca I, Vecchione A
I Clinica Chirurgica, Università degli Studi di Roma La Sapienza, Rome, Italy.
Cancer Lett. 1997 Jan 1;111(1-2):1-5. doi: 10.1016/s0304-3835(96)04472-2.
Nm23 gene codifies for a nucleoside diphosphate kinase allowing the intracellular transduction of the signals. In colorectal cancer nm23 protein expression seems related to the progression of the disease. By immunohistochemistry we have studied the intracytoplasmatic nm23 H1 protein expression in 20 patients affected by colorectal cancer at initial stage. In 12 cases it resulted elevated and in four the disease recurred. The overexpression was not correlated with other prognostic factors. Nm23 H1-positive patients affected by colorectal cancer at initial stage could be considered at risk for disease recurrence and included in a more frequent follow-up protocol.
Nm23基因编码一种核苷二磷酸激酶，可实现信号的细胞内转导。在结直肠癌中，nm23蛋白表达似乎与疾病进展有关。通过免疫组织化学，我们研究了20例早期结直肠癌患者细胞质中nm23 H1蛋白的表达。12例患者表达升高，其中4例疾病复发。这种过表达与其他预后因素无关。早期结直肠癌患者中nm23 H1阳性者可被视为疾病复发风险人群，并纳入更频繁的随访方案。
