Khan S A, Nyce J W
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Cancer Lett. 1997 Jan 1;111(1-2):187-90. doi: 10.1016/s0304-3835(96)04531-4.
Male F-344 rats, when treated with either 150 mg/kg or 300 mg/kg body weight of DHEAS for 14 days, produced a dose-dependent increase in liver weight and peroxisomal beta-oxidation activity, characteristic of peroxisomal proliferation. Contrary to previous observations in vitro, we also found a significant increase in catalase activity in rat liver with the higher dose of the steroid. Furthermore, the in vivo induction of peroxisomal beta-oxidation by DHEAS observed in our study was significantly less than reported in vitro, and also unlike previously reported in vitro results, was approximately equivalent to DHEA administered in vivo.
雄性F-344大鼠，当以150毫克/千克或300毫克/千克体重的硫酸脱氢表雄酮（DHEAS）处理14天时，肝脏重量和过氧化物酶体β-氧化活性呈剂量依赖性增加，这是过氧化物酶体增殖的特征。与之前的体外观察结果相反，我们还发现，给予较高剂量该类固醇时，大鼠肝脏中的过氧化氢酶活性显著增加。此外，我们的研究中观察到的DHEAS在体内对过氧化物酶体β-氧化的诱导作用明显低于体外报道，而且与之前报道的体外结果不同，其诱导作用与体内给予脱氢表雄酮（DHEA）的情况大致相当。
