DiPietro J A, Hodgson D M, Costigan K A, Hilton S C, Johnson T R
Department of Maternal and Child Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Child Dev. 1996 Oct;67(5):2553-67.
The ontogeny of fetal autonomic, motoric, state, and interactive functioning was investigated longitudinally in a sample of 31 healthy fetuses from 20 weeks through term. Fetal heart rate and movement data were collected during 50 min of doppler-based fetal monitoring at 6 gestational ages. Measures of fetal heart rate and variability, activity level and vigor, behavioral state, and reactivity were derived from these digitized data. Weighted least squares analyses were conducted to model the developmental patterns and to examine the role of maternal and fetal covariates. With advancing gestation, fetuses displayed slower heart rate, increased heart rate variability, reduced but more vigorous motor behavior, coalescence of heart rate and movement patterns into distinct behavioral states, and increasing cardiac responsivity to stimulation. Male fetuses were more active than female fetuses, and greater maternal stress appraisal was associated with reduced fetal heart variability. An apparent period of neurobehavioral transition exists between 28 and 32 weeks. Fetal research methods are evaluated.
对31例从20周龄至足月的健康胎儿样本进行了纵向研究，以探讨胎儿自主、运动、状态和交互功能的个体发生情况。在6个孕龄阶段，通过基于多普勒的胎儿监测，在50分钟内收集胎儿心率和运动数据。从这些数字化数据中得出胎儿心率和变异性、活动水平和活力、行为状态以及反应性的测量值。进行加权最小二乘法分析以模拟发育模式，并检验母体和胎儿协变量的作用。随着孕周增加，胎儿心率减慢，心率变异性增加，运动行为减少但更有活力，心率和运动模式合并为不同的行为状态，并且对刺激的心脏反应性增加。雄性胎儿比雌性胎儿更活跃，母体压力评估越高，胎儿心率变异性越低。在28至32周之间存在一个明显的神经行为过渡期。对胎儿研究方法进行了评估。
