Abo T, Kawamura T
Department of Medical Zoology, Niigata University School of Medicine.
Rinsho Byori. 1997 Jan;45(1):3-12.
Empirically we all know that our immune system varies depending on environmental factors and physical conditions. However, such recognition has remained at an empirical level for a long time without the accumulation of scientific data. The major reason is that the substance and its receptor that connect physical conditions with the immune system have previously been obscure. Adrenergic and cholinergic receptors on leukocytes may be important in understanding that relationship. Furthermore, we have to consider the mutually antagonistic functions of granulocytes and lymphocytes in the body. All stimuli from environmental factors change our physical conditions and subsequent changes in the autonomic nervous system influence our immune system through adrenergic receptors on granulocytes and cholinergic receptors on lymphocytes. Overactivation of granulocytes induces purulent diseases or tissue destruction, whereas overactivation of lymphocytes induces allergic diseases.
从经验上讲，我们都知道我们的免疫系统会因环境因素和身体状况而有所不同。然而，这种认识长期以来一直停留在经验层面，缺乏科学数据的积累。主要原因是，此前连接身体状况与免疫系统的物质及其受体一直不清楚。白细胞上的肾上腺素能和胆碱能受体可能在理解这种关系方面很重要。此外，我们还必须考虑粒细胞和淋巴细胞在体内的相互拮抗作用。环境因素产生的所有刺激都会改变我们的身体状况，随后自主神经系统的变化会通过粒细胞上的肾上腺素能受体和淋巴细胞上的胆碱能受体影响我们的免疫系统。粒细胞过度激活会引发化脓性疾病或组织破坏，而淋巴细胞过度激活会引发过敏性疾病。
