一类新型抗肿瘤剂。III. 经处理细胞的形态学发现。

A novel class of antitumour agents. III. Morphological findings in treated cells.

作者信息

Emminger A, Savage D S

出版信息

Cancer Lett. 1977 Sep;3(3-4):157-62. doi: 10.1016/s0304-3835(77)95248-x.

Abstract

The findings of intracellular light-reflecting droplets and clotted mitoses after incubation of Walker and HeLa cells, human lymphocytes and rat fibroblasts with the synthetic amino steroid, 2beta, 16beta-dipiperidino-5alpha-androstane-3-alpha,17beta-diol dipivalate (DAP) were examined in detail. An interaction of DAP with the cellular membranes in all stages of cell life, with the exception of the Go-phase, is postulated.

摘要

在用合成氨基类固醇2β，16β - 二哌啶基 - 5α - 雄甾烷 - 3α，17β - 二醇二特戊酸酯（DAP）孵育沃克癌肉瘤细胞、海拉细胞、人淋巴细胞和大鼠成纤维细胞后，对细胞内光反射液滴和凝块有丝分裂的发现进行了详细研究。推测DAP在细胞生命的所有阶段（除G0期外）都与细胞膜相互作用。