活性炭血液灌流对意外过量服用后喷他脒异硫氰酸盐清除率的影响。
Effect of charcoal hemoperfusion on clearance of pentamidine isethionate after accidental overdose.
作者信息
Watts R G, Conte J E, Zurlinden E, Waldo F B
机构信息
Division of Hematology-Oncology, University of Alabama at Birmingham 35233, USA.
出版信息
J Toxicol Clin Toxicol. 1997;35(1):89-92. doi: 10.3109/15563659709001171.
BACKGROUND
Pentamidine isethionate is an antimicrobial agent effective in the treatment of Pneumocystis carinii pneumonia, trypanosomiasis and leishmaniasis. Severe and fatal toxicity is reported with pentamidine use.
CASE REPORT
A patient received an accidental overdose (40 times the prescribed dose) of intravenous pentamidine due to a pharmacy mixing error. Charcoal hemoperfusion was utilized to attempt to lower the serum concentration of pentamidine and lessen toxicity.
RESULTS
Measurement of pentamidine concentrations in the patient's blood demonstrates a beneficial effect of hemoperfusion.
CONCLUSIONS
Charcoal hemoperfusion may represent a useful modality in the management of pentamidine isethionate overdosage.
背景
乙磺半胱氨酸戊烷脒是一种抗菌剂，对治疗卡氏肺孢子虫肺炎、锥虫病和利什曼病有效。据报道，使用戊烷脒会出现严重和致命的毒性。
病例报告
一名患者因药房配药错误意外静脉注射过量戊烷脒（规定剂量的40倍）。采用活性炭血液灌流试图降低戊烷脒的血清浓度并减轻毒性。
结果
对患者血液中戊烷脒浓度的测量显示出血液灌流的有益效果。
结论
活性炭血液灌流可能是治疗乙磺半胱氨酸戊烷脒过量的一种有用方法。
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