Paans A M, Pruim J, van Waarde A, Willemsen A T, Vaalburg W
PET Center, Groningen University Hospital, The Netherlands.
Baillieres Clin Endocrinol Metab. 1996 Oct;10(4):497-510. doi: 10.1016/s0950-351x(96)80666-5.
The amino acid incorporation rate, generally described as protein synthesis rate or PSR, can be assessed in vivo using carboxylic-labelled amino acids such as L-[1-11C]tyrosine and PET. In animals, labelled tissue metabolites are below 4% of total tissue radioactivity and are therefore neglected in the model. Labelled plasma metabolites on the other hand rise continuously to 50% of total plasma radioactivity at 40 minutes. After correction of the total plasma radioactivity for the metabolite fraction, a Patlak analysis may be performed to calculate the PSR. A number of applications in the field of oncology were presented. The use of L-[1-11C]tyrosine in the study of metabolic disease was also discussed. It is concluded that the application of [11C]tyrosine-PET in a clinical setting is of interest for an increasing number of diseases.
氨基酸掺入率，通常称为蛋白质合成率或PSR，可以使用羧基标记的氨基酸（如L-[1-11C]酪氨酸）和正电子发射断层扫描（PET）在体内进行评估。在动物中，标记的组织代谢物低于总组织放射性的4%，因此在模型中被忽略。另一方面，标记的血浆代谢物在40分钟时持续上升至总血浆放射性的50%。在对代谢物部分校正总血浆放射性后，可以进行Patlak分析以计算PSR。文中介绍了肿瘤学领域的一些应用。还讨论了L-[1-11C]酪氨酸在代谢疾病研究中的应用。得出的结论是，[11C]酪氨酸-PET在临床环境中的应用对于越来越多的疾病具有重要意义。
