Pasquali R, Vicennati V, Scopinaro N, Marinari G, Simonelli A, Flamia R, Casimirri F, Gagliardi L
Dipartimento di Medicina Interna & Gastroenterologia, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Int J Obes Relat Metab Disord. 1997 Jan;21(1):1-5. doi: 10.1038/sj.ijo.0800351.
To investigate the effects of weight loss on sex hormone-binding globulin (SHBG) in massively obese males and whether normal SHBG concentrations could be obtained regardless or not of the achievement of normal body weight values.
Sera were collected for SHBG determination from 63 massively obese men, partly before they underwent biliopancreatic diversion (pre-op group = 11) and partly during the post-surgical follow up (post-op group = 52), and twenty normal weight healthy control men.
Serum SHBG was measured using a noncompetitive liquid-phase immunoradiometric assay.
Baseline general characteristics were similar in both obese groups. Obese patients in the post-op group had lost 46.4 +/- 2.9 kg since they had undergone operation, namely during a mean period of 14.9 +/- 13.8 (range 1-58) months follow up. Obese groups had significantly lower SHBG than normal weight controls (66.2 +/- 18.6 nmol/l). However, pre-op obese (19.9 +/- 5.5 nmol/l) had significantly lower values than post-op obese subjects (45.5 +/- 24.8 nmol/l; P < 0.001). There were a highly significant correlation between SHBG and individual BMI values (r = -0.629; P < 0.001). Moreover, the post-op obese with BMI values lower or equal to 28 had significantly higher SHBG concentrations than those with BMI greater than 28 (62.8 +/- 22.2 nmol/l vs 32.1 +/- 19.6 nmol/l; P < 0.001), but not significantly different with respect to normal weight controls.
Massively obese men weight loss can completely reverse SHBG abnormalities, which can be restored to the normal range when near-normal body weight is achieved. Since reduced SHBG concentrations can be an independent risk factor for the development of diabetes and cardiovascular disease, this represents an additional benefit of weight loss program in massively obese individuals.
研究体重减轻对极度肥胖男性性激素结合球蛋白（SHBG）的影响，以及无论体重是否恢复正常，SHBG浓度能否恢复正常。
收集了63名极度肥胖男性的血清用于检测SHBG，其中部分在接受胆胰分流术前（术前组=11例），部分在术后随访期间（术后组=52例），以及20名体重正常的健康对照男性。
采用非竞争性液相免疫放射分析测定血清SHBG。
两组肥胖组的基线一般特征相似。术后组肥胖患者自手术以来平均减重46.4±2.9kg，随访时间平均为14.9±13.8（范围1 - 58）个月。肥胖组的SHBG显著低于体重正常对照组（66.2±18.6nmol/L）。然而，术前肥胖患者（19.9±5.5nmol/L）的值显著低于术后肥胖患者（45.5±24.8nmol/L；P<0.001）。SHBG与个体BMI值之间存在高度显著相关性（r = -0.629；P<0.001）。此外，术后BMI值低于或等于28的肥胖患者的SHBG浓度显著高于BMI大于28的患者（62.8±22.2nmol/L对32.1±19.6nmol/L；P<0.001），但与体重正常对照组无显著差异。
极度肥胖男性体重减轻可完全逆转SHBG异常，当体重接近正常时可恢复至正常范围。由于SHBG浓度降低可能是糖尿病和心血管疾病发生的独立危险因素，这代表了减重计划对极度肥胖个体的额外益处。
