Jauniaux E, Lees C, Jurkovic D, Campbell S, Gulbis B
Academic Department of Obstetrics and Gynaecology, University College London, United Kingdom.
Am J Obstet Gynecol. 1997 Jan;176(1 Pt 1):33-6. doi: 10.1016/s0002-9378(97)80007-5.
Our aim was to investigate the transfer of inulin from the mother to the first-trimester fetus.
A bolus of inulin (5 mg/kg) was administered to nine healthy volunteers with pregnancies between 6 and 12 weeks of gestation scheduled for elective termination of pregnancy. Coelomic and amniotic fluid samples were obtained from the corresponding cavities between 8 and 25 minutes after the end of the bolus of inulin. Fetal fluid inulin concentrations were compared with those of matched samples of maternal blood and urine collected simultaneously.
Inulin was detected in all fetal and maternal samples. A trend toward an increasing inulin concentration was noted in the exocoelomic cavity with advancing time. Coelomic and maternal serum inulin concentrations were similar within 20 minutes after injection. Amniotic inulin concentrations were always lower than coelomic concentrations irrespective of gestational age or advancing time after injection.
Inulin crosses the first-trimester human placenta from 7 weeks of gestation in quantities that yield measurable concentrations in both coelomic and amniotic fluids. These results suggest that the study of drug transfer in the first trimester of human pregnancy is feasible with use of samples obtained from the exocoelomic cavity.
我们的目的是研究菊粉从母体向孕早期胎儿的转运情况。
给9名妊娠6至12周且计划进行选择性终止妊娠的健康志愿者静脉注射一剂菊粉（5毫克/千克）。在菊粉注射结束后8至25分钟内，从相应体腔获取体腔液和羊水样本。将胎儿液中的菊粉浓度与同时采集的匹配母体血液和尿液样本的浓度进行比较。
在所有胎儿和母体样本中均检测到菊粉。随着时间推移，发现体腔中的菊粉浓度有升高趋势。注射后20分钟内，体腔和母体血清中的菊粉浓度相似。无论胎龄或注射后的时间如何，羊水中的菊粉浓度始终低于体腔中的浓度。
从妊娠7周起，菊粉可穿过孕早期的人胎盘，其含量能在体腔液和羊水中产生可测量的浓度。这些结果表明，利用从体腔获取的样本研究人类妊娠早期的药物转运是可行的。
