由Mec1sc/Rad3sp DNA结构检查点途径控制细胞周期停滞
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.
作者信息
Carr A M
机构信息
MRC Cell Mutation Unit, Sussex University, Falmer BN1 9RR UK. a.m.
出版信息
Curr Opin Genet Dev. 1997 Feb;7(1):93-8. doi: 10.1016/s0959-437x(97)80115-3.
PMID:9024628
Abstract
The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPKcs, suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.
摘要
Mec1（酵母）/Rad3（裂殖酵母）蛋白家族在细胞的检查点途径中起着核心作用。与不同生物体相比，Mec1（酵母）/Rad3（裂殖酵母）上下游的功能既有相似之处，也有不同之处。与相关蛋白DNA依赖蛋白激酶催化亚基（DNAPKcs）的类比表明，不同的亚基可能会响应特定的DNA或DNA-蛋白质结构而激活Mec1（酵母）/Rad3（裂殖酵母）。
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