Ozherelkov S V, Semenova I B, Vagin V V, Nikol'skaia K A, Savanenko A V, Semenov B F
Zh Mikrobiol Epidemiol Immunobiol. 1996 Jul-Aug(4):71-4.
The action of information stress for 14 days leads to the development of immunosuppression, which is manifested by the suppression of humoral response to sheep red blood cells (SRBC) and the decrease of resistance to Langat virus having low pathogenicity. As shown in this investigation, an immunomodifier, purified staphylococcal toxoid (PST), protects experimental animals from the immunosuppressive effect of information stress. After the injection of PST to stress-affected mice in doses of 15 or 1.5 binding units per animal on days 9, 11 and 13 of the experiment their humoral response to SRBC and resistance to Langat virus are partially restored (by 45-60%).
信息应激作用14天会导致免疫抑制的发生,其表现为对绵羊红细胞(SRBC)的体液反应受到抑制以及对低致病性的兰加特病毒的抵抗力下降。如本研究所示,一种免疫调节剂——纯化葡萄球菌类毒素(PST),可保护实验动物免受信息应激的免疫抑制作用。在实验的第9、11和13天,以每只动物15或1.5结合单位的剂量向受应激影响的小鼠注射PST后,它们对SRBC的体液反应和对兰加特病毒的抵抗力部分恢复(恢复45% - 60%)。