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[纯化葡萄球菌产毒菌素免疫疗法的实验验证]

[An experimental validation of immunotherapy with purified staphylococcal anatoxin].

作者信息

Semenova I B, Prozorovskaia K N, Vargin V V, Antonova L V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1993 Mar-Apr(2):99-101.

PMID:8059583
Abstract

Inbred mice have proved to be a promising model for the evaluation of antigen-specific and antigen-nonspecific immunomodulating activity of purified staphylococcal toxoid in humans. This toxoid induces the formation of pronounced humoral response to homologous and heterologous infections in humans and mice. In animal experiments purified staphylococcal toxoid has shown its capacity for the correction of secondary immune deficiency of different origin; when introduced into humans having secondary immunodeficiency associated with bacterial infections of different etiology, the preparation reproduces this effect.

摘要

近交系小鼠已被证明是评估纯化葡萄球菌类毒素在人类中的抗原特异性和非特异性免疫调节活性的一个有前景的模型。这种类毒素可诱导人类和小鼠对同源和异源感染产生明显的体液反应。在动物实验中,纯化葡萄球菌类毒素已显示出纠正不同来源继发性免疫缺陷的能力;当将其引入患有与不同病因细菌感染相关的继发性免疫缺陷的人类时,该制剂能重现这种效果。

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