Prusachenko V K, Gatsura V V
Farmakol Toksikol. 1977 Jul-Aug;40(4):403-7.
When reproducing ischemia of the myocardium in acute experiments on rabbits and in tests with the isolated rabbit's heart an elevated permeability of the myocardial histo-blood barriers (HBB) to sodium sulphacyl in the region of ischemia and its boundary zone was established. Upon introduction of isadrine (2 mg/kg and 2-10-6 M) and anapriline (1 and 2.5 mg/kg; 2-10-6 and 10-5M) the permeability of the HBB to sodium sulphacyl within the ischemia zone and in areas of the myocardium contiguous to it diminished. The permeability of the myocardial HBB in the intact zone did not change under the effect of the drugs. In in vitro experiments with erythrocytes by using the fluorescent test and methods for determination of the osmotic resistance the drugs were found to display the membranotropic activity. From the in vitro tests it follows that anapriline and isadrine exercise no antiprotease action.
在对家兔进行的急性实验以及对离体兔心进行的试验中，当复制心肌缺血时，发现缺血区域及其边界区的心肌组织 - 血屏障（HBB）对磺胺酰钠的通透性升高。注射异丙肾上腺素（2毫克/千克和2×10⁻⁶摩尔）和心得安（1和2.5毫克/千克；2×10⁻⁶和10⁻⁵摩尔）后，缺血区内以及与其相邻的心肌区域的HBB对磺胺酰钠的通透性降低。在药物作用下，完整区域的心肌HBB通透性未发生变化。在体外对红细胞进行的实验中，通过荧光试验和测定渗透压抵抗力的方法发现，这些药物具有膜作用活性。从体外试验可以看出，心得安和异丙肾上腺素没有抗蛋白酶作用。
