Gendenshteĭn E I, Volkova N D
Kardiologiia. 1976 Feb;16(2):127-30.
In 95 feline experiments it was established that coronary artery occlusion does not affect the Strophantin lethal dose, but it increases the sensitivity to the arrhythmogenic effect of the cardiac glycoside after 24-48 hours. Premedication of intact animals with such a beta-adrenergic blocking agent as Anapriline (Inderal) significantly increases the toolerance of Strophantin while the stimulation of the beta-adrenergic structures with Isadrine, on the contrary, decreases the arrhythmogenic and lethal dose of Strophantin. In coronary circulation disorders the pharmacological block of the adrenergic heart innervation did not produce any significant reduction of the sensitivity to the cardiac glycoside.
在95只猫的实验中发现，冠状动脉闭塞并不影响毒毛旋花子苷的致死剂量，但在24至48小时后会增加对强心苷致心律失常作用的敏感性。用心得安（Inderal）这种β-肾上腺素能阻滞剂对正常动物进行预处理可显著提高对毒毛旋花子苷的耐受性，而用异丙肾上腺素刺激β-肾上腺素能结构则相反，会降低毒毛旋花子苷的致心律失常和致死剂量。在冠状动脉循环障碍中，肾上腺素能心脏神经支配的药理阻断并未使对强心苷的敏感性有任何显著降低。
