Liberman S S, Egorova E F
Farmakol Toksikol. 1977 Jul-Aug;40(4):442-5.
The effect produced by pyrazidol, a new tricyclic antidepressant, on changes in the blood sugar concentration caused by epinephrine and serotonin was investigated. Pyrazidol appreciably intensifies the effect of serotonin in intact and adrenalectomized animals. Under the influence of pyrazidol the action of epinephrine in intact animals also gains in strength, while in adrenalectomized animals pyrazidol lessens the hyperglycemic effect of epinephrine. Since the introduction of cortisol to adrenalectomized animals restores the effect of pyrazidol it is suggested that the influence of pyrazidol on the blood sugar concentration is accomplished with participation of glucocorticoids.
研究了新型三环类抗抑郁药吡唑醇对肾上腺素和血清素引起的血糖浓度变化的影响。吡唑醇可显著增强血清素对完整动物和肾上腺切除动物的作用。在吡唑醇的影响下，完整动物体内肾上腺素的作用也会增强，而在肾上腺切除动物中，吡唑醇会减弱肾上腺素的高血糖作用。由于给肾上腺切除动物注射皮质醇可恢复吡唑醇的作用，因此提示吡唑醇对血糖浓度的影响是在糖皮质激素的参与下实现的。
