Polukhina L M, Padeĭskaia E N, Granik E M, Pershin G N
Farmakol Toksikol. 1977 Jul-Aug;40(4):478-81.
By using spectrochromatography the dioxidine and quinoxidine passage with urine, depending upon their doses and the method of introduction, was studied in tests on mice. On its enteral or subcutaneous introduction dioxidine is found in the urine within a period of 7-to 24 hours (depending upon the dose administered). With its maximum concentration it is definable within 1 hour. The animals' urine showed no presence of quinoxidine. In mice receiving quinoxidine the urine is found to contain the product of its disacetylization-dioxidine. The dynamics of the dioxidine excretion with urine in mice receiving quinoxidine is in line with regularities common to the passage of dioxidine following its administration to mice.
通过光谱色谱法，在小鼠试验中研究了二氧嗪和喹喔啉随尿液的排出情况，这取决于它们的剂量和引入方法。经肠道或皮下引入后，二氧嗪在7至24小时内出现在尿液中（取决于给药剂量）。在最大浓度时，1小时内即可检测到。动物尿液中未发现喹喔啉。在接受喹喔啉的小鼠中，尿液中发现了其去乙酰化产物——二氧嗪。接受喹喔啉的小鼠尿液中二氧嗪的排泄动态符合给小鼠注射二氧嗪后其排出的一般规律。
