Gus'kova T A, Berliand E A, Popova V N, Romanova L K, Chicherina L A
Farmakol Toksikol. 1984 Jan-Feb;47(1):104-9.
The toxicity of dioxydin and quinoxidine was studied in experiments on rats and mice given the drugs intravenously. The target organs for both drugs are the adrenals. The pathological process develops in their cortical layer and continues progressing after the drugs are discontinued. Quinoxidine appeared less toxic owing to which the pathological signs in the adrenals were reversible in the majority of animals given this drug in a dose of 100 mg/kg.
在给大鼠和小鼠静脉注射二氧啶和喹喔星的实验中研究了它们的毒性。两种药物的靶器官都是肾上腺。病理过程在肾上腺皮质层发展，并且在停药后仍持续进展。喹喔星的毒性似乎较小，因此，在大多数以100mg/kg剂量给予该药物的动物中，肾上腺的病理体征是可逆的。
