Anderson K E, Sellers T A, Chen P L, Rich S S, Hong C P, Folsom A R
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA.
Cancer. 1997 Feb 1;79(3):494-9.
The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity. Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma, and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992.
All participants were between the ages of 55 and 69 and held a valid Iowa driver's license. A total of 472 women in the cohort (1.35%) reported a history of SLS at baseline. Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa. Data were analyzed using Cox proportional hazards regression.
During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS. Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI). Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P < 0.01), they were not more likely to develop breast carcinoma (relative risk [RR] = 1.2; 95% confidence interval [CI] = 0.7-2). Adjustment for age at menarche, age at menopause, parity, oral contraceptive use, BMI, waist-to-hip ratio, and family history of breast carcinoma lowered the RR to 1 (95% CI = 0.6-1.9.
Despite the high risk profiles of some women with SLS, these results do not suggest that the syndrome per se is associated with an increased risk of postmenopausal breast carcinoma.
斯坦因-莱文塔尔综合征（SLS）于1935年首次被描述，其特征为不孕、雄激素过多和肥胖。由于这种表型代表了绝经后乳腺癌危险因素的聚集，并且一般而言，激素失衡是该疾病的基础，作者在1986年召集的34835名无癌女性队列中研究了自我报告的SLS与乳腺癌发病率之间的关联，并随访至1992年。
所有参与者年龄在55至69岁之间，并持有有效的爱荷华州驾照。该队列中共有472名女性（1.35%）在基线时报告有SLS病史。每年使用爱荷华州州立健康登记处来确定乳腺癌的发病病例。使用Cox比例风险回归分析数据。
在随访期间，有883例乳腺癌发病病例，其中14例发生在报告有SLS病史的女性中。有SLS的女性比没有SLS的女性更有可能报告生育问题和月经不规律，但在体重指数（BMI）方面未观察到显著差异。尽管有SLS的女性报告患良性乳腺疾病的可能性是没有SLS的女性的1.8倍（P < 0.01），但她们患乳腺癌的可能性并不更高（相对风险[RR] = 1.2；95%置信区间[CI] = 0.7 - 2）。对初潮年龄、绝经年龄、产次、口服避孕药使用情况、BMI、腰臀比和乳腺癌家族史进行调整后，RR降至1（95% CI = 0.6 - 1.9）。
尽管一些患有SLS的女性有较高的风险特征，但这些结果并不表明该综合征本身与绝经后乳腺癌风险增加有关
