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多囊卵巢综合征与乳腺癌之间的关联：一项荟萃分析。

The association between polycystic ovary syndrome and breast cancer: a meta-analysis.

作者信息

Shobeiri Fatemeh, Jenabi Ensiyeh

机构信息

Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

出版信息

Obstet Gynecol Sci. 2016 Sep;59(5):367-72. doi: 10.5468/ogs.2016.59.5.367. Epub 2016 Sep 13.

DOI:10.5468/ogs.2016.59.5.367
PMID:27668199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5028643/
Abstract

OBJECTIVE

The results of epidemiological studies investigated the association between polycystic ovary syndrome (PCOS) and the breast cancer are inconsistent. This meta-analysis was conducted to estimate the association between PCOS and the breast cancer risk. We searched PubMed, Web of Science, and Scopus for observational studies until June 2015. Data were independently extracted and analyzed using 95% odds ratio, and confidence intervals (CIs) based on the random-effects models.

METHODS

We identified 970 references and conducted eight studies with 45,470 participants and 243,064 person- year.

RESULTS

The association between PCOS and the breast cancer risk in case-control studies 0.87 (95% CI, 0.44 to 1.31) and that of cohort studies was estimated 1.18 (95% CI, 0.93 to 1.43).

CONCLUSION

This meta-analysis demonstrated that PCOS no does increase the risk of breast cancer. Further prospective cohort studies are needed to provide convincing evidence in order to PCOS can increase or not effect on the risk of the breast cancer.

摘要

目的

流行病学研究调查多囊卵巢综合征（PCOS）与乳腺癌之间关联的结果并不一致。本荟萃分析旨在评估PCOS与乳腺癌风险之间的关联。我们检索了PubMed、科学网和Scopus数据库，查找截至2015年6月的观察性研究。数据由独立人员提取，并采用基于随机效应模型的95%比值比及置信区间（CI）进行分析。

方法

我们识别出970篇参考文献，并纳入8项研究，涉及45470名参与者和243064人年。

结果

病例对照研究中PCOS与乳腺癌风险之间的关联为0.87（95%CI，0.44至1.31），队列研究中的估计值为1.18（95%CI，0.93至1.43）。

结论

本荟萃分析表明，PCOS不会增加患乳腺癌的风险。需要进一步开展前瞻性队列研究以提供令人信服的证据，从而明确PCOS是否会增加乳腺癌风险或对其风险有无影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/a3ab34f0baf7/ogs-59-367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/76075cdef1b4/ogs-59-367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/64d9bb5b2107/ogs-59-367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/a3ab34f0baf7/ogs-59-367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/76075cdef1b4/ogs-59-367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/64d9bb5b2107/ogs-59-367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb33/5028643/a3ab34f0baf7/ogs-59-367-g003.jpg

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