Hann D M, Jacobsen P B, Martin S C, Kronish L E, Azzarello L M, Fields K K
Psychosocial Oncology Program, H Lee Moffitt Cancer Center, Tampa, FL, USA.
Bone Marrow Transplant. 1997 Feb;19(3):257-64. doi: 10.1038/sj.bmt.1700651.
As more women are treated with bone marrow transplantation (BMT) for breast cancer, there is growing interest in quality of life (QOL) following treatment. Although there have been some clinical studies of QOL following BMT, this area has received little systematic attention. In particular, it is unclear how QOL for women treated with BMT for breast cancer differs from that which might be expected for 'healthy' women of about the same age. To address this issue, we compared QOL reported by women treated with autologous BMT for breast cancer with that of a group of women of similar age with no history of cancer. In addition, we examined the relationship of demographic factors, medical factors, and self-reported symptom prevalence, severity, and distress to QOL in post-BMT patients. All participants completed the SF-36 Health Survey developed from the Medical Outcomes Study (SF-36). Post-BMT patients also completed the ECOG Performance Status Rating Scale (PSR) and the Memorial Symptom Assessment Scale (MSAS). Results indicated that, compared to the women with no cancer history, post-BMT patients reported significantly impaired physical functioning, physical role functioning, general health, vitality, social functioning, and emotional role functioning. Impaired QOL following BMT was significantly associated with lower income, a longer time to engraftment, longer hospital stay, poor performance status, and greater symptom prevalence, severity, and distress. The problems identified in this study may be important targets for intervention when trying to improve QOL following BMT.
随着越来越多的女性接受乳腺癌骨髓移植（BMT）治疗，人们对治疗后的生活质量（QOL）的关注日益增加。尽管已有一些关于BMT后生活质量的临床研究，但该领域很少受到系统关注。特别是，尚不清楚接受BMT治疗的乳腺癌女性的生活质量与年龄相仿的“健康”女性预期的生活质量有何不同。为解决这一问题，我们将接受自体BMT治疗的乳腺癌女性报告的生活质量与一组无癌症病史的同龄女性的生活质量进行了比较。此外，我们还研究了人口统计学因素、医学因素以及自我报告的症状发生率、严重程度和痛苦程度与BMT后患者生活质量之间的关系。所有参与者都完成了由医疗结果研究（SF - 36）开发的SF - 36健康调查。BMT后患者还完成了东部肿瘤协作组（ECOG）体能状态评分量表（PSR）和纪念症状评估量表（MSAS）。结果表明，与无癌症病史的女性相比，BMT后患者在身体功能、身体角色功能、总体健康、活力、社会功能和情感角色功能方面的报告明显受损。BMT后生活质量受损与低收入、更长的植入时间、更长的住院时间、较差的体能状态以及更高的症状发生率、严重程度和痛苦程度显著相关。本研究中确定的问题可能是试图改善BMT后生活质量时重要的干预目标。
