细胞释放膜结合碱性磷酸酶的物理化学和病理生理因素。
Physicochemical and pathophysiological factors in the release of membrane-bound alkaline phosphatase from cells.
作者信息
Moss D W
机构信息
Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Clin Chim Acta. 1997 Jan 3;257(1):133-40. doi: 10.1016/s0009-8981(96)06438-8.
PMID:9028630
Abstract
Alkaline phosphatase is bound to cell membranes by a glycan phosphatidylinositol anchoring domain. The structure of this domain and ways in which it may be cleaved by chemical and enzymatic means provide a basis for understanding the solubilization of alkaline phosphatase from tissues in vitro and in vivo and the generation of isoforms.
摘要
碱性磷酸酶通过聚糖磷脂酰肌醇锚定结构域与细胞膜结合。该结构域的结构以及其可通过化学和酶促方法被切割的方式，为理解体外和体内从组织中溶解碱性磷酸酶以及同工型的产生提供了基础。
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