Ferri C, Bellini C, Desideri G, Baldoncini R, De Siati L, Santucci A
Institute of Clinica Medica I, University La Sapienza, Andrea Cesalpino Foundation, Rome, Italy.
Diabetologia. 1997 Jan;40(1):100-2. doi: 10.1007/s001250050649.
Circulating endothelin-1 concentration was evaluated in 93 lean patients with essential hypertension, of whom 16 had impaired glucose tolerance and hyperlipidaemia, 25 had impaired glucose tolerance, 28 had hyperlipidaemia and 24 had no metabolic abnormalities; we also studied 22 control subjects. All groups were age- and sex-matched. Plasma endothelin-1 levels were higher (p < 0.05) in hypertensive patients with impaired glucose tolerance and hyperlipidaemia than in the remaining groups and were directly correlated with fasting insulin levels (r = 0.506, p = 0.045). Therefore, circulating endothelin-1 concentrations are elevated in hypertensive patients with a high-risk profile due to the presence of metabolic abnormalities, and might favour the development of vascular damage.
对93例原发性高血压的瘦患者进行了循环内皮素-1浓度评估，其中16例有糖耐量受损和高脂血症，25例有糖耐量受损，28例有高脂血症，24例无代谢异常；我们还研究了22名对照受试者。所有组在年龄和性别上相匹配。糖耐量受损和高脂血症的高血压患者的血浆内皮素-1水平高于其余组（p<0.05），且与空腹胰岛素水平直接相关（r = 0.506，p = 0.045）。因此，由于存在代谢异常，具有高危特征的高血压患者循环内皮素-1浓度升高，这可能有利于血管损伤的发展。
