Croyle R T, Smith K R, Botkin J R, Baty B, Nash J
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Health Psychol. 1997 Jan;16(1):63-72. doi: 10.1037//0278-6133.16.1.63.
The short-term psychological responses of 60 adult women tested for a BRCA1 gene mutation associated with a high risk of breast and ovarian cancer were investigated. Participants were members of a large kindred enrolled in an ongoing prospective study of the psychosocial impact of genetic testing. Initial results from participants who completed both the pretest baseline and the 1-2 week posttest follow-up interviews are reported. Gene mutation carriers manifested significantly higher levels of test-related psychological distress, as measured by the Impact of Event Scale, when compared with noncarriers. The highest levels of test-related distress were observed among mutation carriers with no history of cancer or cancer-related surgery. Although general distress (state anxiety) declined after testing, carriers were more distressed than noncarriers at follow-up.
对60名成年女性进行了与乳腺癌和卵巢癌高风险相关的BRCA1基因突变检测，并对其短期心理反应进行了调查。参与者是一个大家族的成员，该家族参与了一项关于基因检测心理社会影响的正在进行的前瞻性研究。报告了完成测试前基线和测试后1 - 2周随访访谈的参与者的初步结果。与非携带者相比，通过事件影响量表测量，基因突变携带者表现出与检测相关的心理困扰水平显著更高。在没有癌症或癌症相关手术史的突变携带者中，观察到与检测相关的困扰水平最高。尽管检测后一般困扰（状态焦虑）有所下降，但在随访时，携带者比非携带者更困扰。
