Chen R, Gerloff C, Hallett M, Cohen L G
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
Ann Neurol. 1997 Feb;41(2):247-54. doi: 10.1002/ana.410410216.
Functional imaging and behavioral studies suggest involvement of the ipsilateral hemisphere in hand movements, particularly of the left hand. If this is so, transient disturbance of the motor cortex (M1) with repetitive transcranial magnetic stimulation (rTMS) may affect ipsilateral motor sequences, and the effects may differ on the two sides. We studied 15 right-handed subjects who played a simple and a complex piano sequence for 8 seconds each. Two seconds after the beginning of each sequence, rTMS was delivered to the ipsilateral or contralateral M1, or directed away from the head (control trial). Ipsilateral M1 stimulation on either side induced timing errors in both sequences, and with the complex sequence induced more timing errors in the left hand than in the right hand. Errors of the right hand with both sequences occurred in the stimulation period only, but errors of the left hand with the complex sequence occurred in both the stimulation and poststimulation periods. We conclude that the ipsilateral M1 is involved in fine finger movements. The left hemisphere plays a greater role in timing ipsilateral complex sequences than the right hemisphere and may be more involved in the processing of complex motor programs.
功能成像和行为研究表明，同侧半球参与手部运动，尤其是左手的运动。如果真是这样，重复经颅磁刺激（rTMS）对运动皮层（M1）的短暂干扰可能会影响同侧运动序列，且两侧的影响可能不同。我们研究了15名右利手受试者，他们分别弹奏一个简单和一个复杂的钢琴序列，每个序列持续8秒。在每个序列开始后2秒，将rTMS施加于同侧或对侧M1，或远离头部（对照试验）。对两侧同侧M1的刺激在两个序列中均诱发了时间误差，且在复杂序列中，左手诱发的时间误差比右手更多。两个序列中右手的误差仅出现在刺激期，但复杂序列中左手的误差出现在刺激期和刺激后期。我们得出结论，同侧M1参与精细手指运动。左半球在同侧复杂序列的时间控制中比右半球发挥更大作用，可能更多地参与复杂运动程序的处理。
