Levine J, Kurtzman L, Rapoport A, Zimmerman J, Bersudsky Y, Shapiro J, Belmaker R H, Agam G
Ministry of Health Mental Health Center. Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
J Neural Transm (Vienna). 1996;103(12):1457-62. doi: 10.1007/BF01271260.
CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.
据报道，脑脊液中的肌醇在抑郁症患者中含量降低，且已有报道称肌醇对抑郁症治疗有效。我们对18名未服用药物的抑郁症患者和36名正常对照者的脑脊液肌醇进行了研究；这些抑郁症患者随后参加了一项开放试验，接受每日18克肌醇治疗，为期4周。抑郁症患者和对照组在治疗前脑脊液肌醇水平上没有差异。脑脊液肌醇水平无法预测汉密尔顿抑郁量表对4周肌醇治疗的反应。
