Levine J, Barak Y, Kofman O, Belmaker R H
Abarbanel Mental Health Center, Bat Yam, Israel.
Isr J Psychiatry Relat Sci. 1995;32(1):14-21.
A recent controlled double-blind study of 28 patients treated with 12 gm daily of inositol or placebo revealed significant antidepressant effect for this second messenger precursor. Patients were followed-up by interview and Hamilton Depression Scale 10-12 months after the end of the study. Half of the patients who had responded well to inositol relapsed rapidly after inositol discontinuation whereas none of those who responded to placebo relapsed rapidly after placebo cessation. Klein suggested that true drug responders to tricyclic antidepressants respond slowly and gradually whereas placebo responders improve early in an abrupt fashion. However, in the recent study both inositol and placebo responders improved at similar rates. Hamilton Depression Scale Scores 10-12 months after completion of the study were not significantly different between those who had responded and those who had not responded to inositol or to placebo.
最近一项针对28名患者的对照双盲研究显示，每日服用12克肌醇或安慰剂，这种第二信使前体具有显著的抗抑郁作用。研究结束后10 - 12个月，通过访谈和汉密尔顿抑郁量表对患者进行随访。对肌醇反应良好的患者中，有一半在停用肌醇后迅速复发，而对安慰剂有反应的患者在停用安慰剂后均未迅速复发。克莱因认为，对三环类抗抑郁药真正有药物反应的患者反应缓慢且逐渐改善，而安慰剂反应者则早期迅速改善。然而，在最近的研究中，肌醇和安慰剂反应者的改善速度相似。研究完成后10 - 12个月，对肌醇或安慰剂有反应和无反应的患者的汉密尔顿抑郁量表评分没有显著差异。
