Menerath J M, Cluzel J, Droy-Lefaix M T, Doly M
Facultés de Médecine et de Pharmacie, INSERM U.71. Clermont-Ferrand, France.
J Ocul Pharmacol Ther. 1997 Feb;13(1):81-8. doi: 10.1089/jop.1997.13.81.
Electroretinographic exploration is an effective approach to evaluate retinal function. In order to investigate physiopathological mechanisms and evaluate potentially protective therapies for retinal ischemia, we developed three experimental models: the first two on isolated retina, with ischemia induced by either stopping perfusion or clamping the ophthalmic artery, and the third, in vivo, with ischemia induced by ocular hypertonia. Since free radicals are implicated in the formation of post-ischemic lesions, we evaluated the protective effects of drugs known to be free radical scavengers and of an immunomediator antagonist, an anti-PAF (platelet activating factor) agent.
视网膜电图检查是评估视网膜功能的一种有效方法。为了研究视网膜缺血的生理病理机制并评估其潜在的保护性治疗方法，我们建立了三种实验模型：前两种是在离体视网膜上，通过停止灌注或夹闭眼动脉诱导缺血，第三种是在体内，通过眼内高压诱导缺血。由于自由基与缺血后病变的形成有关，我们评估了已知为自由基清除剂的药物以及一种免疫介质拮抗剂（一种抗血小板活化因子药物）的保护作用。
