Bowhay S, Timms P
Clinical Pharmacokinetics Laboratory, Stobhill N.H.S. Trust, Glasgow, Scotland.
Ther Drug Monit. 1997 Feb;19(1):117-9. doi: 10.1097/00007691-199702000-00023.
Commercially available immunoassays for vancomycin have been reported to overestimate serum vancomycin concentrations by varying degrees in patients with renal impairment, particularly those on peritoneal dialysis, by interference with crystalline degradation product-1 (CDP-1). To date this interference has not been reported in any other patient population. This report describes vancomycin fluorescence polarisation immunoassay (FPIA) interference in a patient with only mildly impaired renal function. At this time it is not possible to confirm that the interference was caused by CDP-1.
据报道，市售的万古霉素免疫测定法在肾功能不全患者中，尤其是腹膜透析患者中，会因干扰结晶降解产物-1（CDP-1）而不同程度地高估血清万古霉素浓度。迄今为止，尚未在任何其他患者群体中报道这种干扰。本报告描述了一名肾功能仅轻度受损患者的万古霉素荧光偏振免疫测定法（FPIA）干扰情况。目前尚无法证实这种干扰是由CDP-1引起的。
