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[pi8噬菌体中晚期基因13、17、18和19的功能]

[Functions of the late genes 13, 17, 18 and 19 in pi8 phage].

作者信息

Mishchenko B S, Rybchin V N, San'kova T P

出版信息

Genetika. 1977;13(6):1093-102.

PMID:902987
Abstract

Genes of the right arm of the pi80 phage chromosome were characterized by studying lytic and antigenic activities and replication ability of mutant phages and by electron microscopic examination of their lysates. It is shown that the genes 14, 15 and 16 are early, and the genes 17, 18 and 19 are late. The functions of four genes are determined. The gene 13 is responsible for antigenic activity and for phage host-cell specificity; the gene 17 is a regulator of the late functions; the gene 18 product affects the cell membrane; the gene 19 controls the synthesis of phage endolysine. It is suggested to redesignate the pi80 phage genes 13, 17, 18 and 19 by the letters J, Q, S and R respectively, because these genes fulfil the same functions as the lambda genes J, Q, S and R.

摘要

通过研究突变噬菌体的裂解活性、抗原活性和复制能力,并对其裂解物进行电子显微镜检查,对pi80噬菌体染色体右臂的基因进行了表征。结果表明,基因14、15和16是早期基因,基因17、18和19是晚期基因。确定了四个基因的功能。基因13负责抗原活性和噬菌体宿主细胞特异性;基因17是晚期功能的调节因子;基因18产物影响细胞膜;基因19控制噬菌体内切溶素的合成。建议将pi80噬菌体基因13、17、18和19分别重新命名为字母J、Q、S和R,因为这些基因与λ基因J、Q、S和R具有相同的功能。

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