Matzkies F, Berg G
Fortschr Med. 1977 Jul 21;95(27):1745-7.
After oral application of 100mg of Benzbromarone a significant decrease of the uric acid concentration in the serum up to the 14th day after beginning of the treatment to a mean value of 1,7 mg/100 ml is achieved; while the application of 50 mg of Benzbromarone reduces the uric acid concentration only to a value of 3,4 mg/100 ml. Thereby the differences amounts to about 1,7 mg/100 ml. The urate elimination increases after 100 as well as after 50 mg of Benzbromarone. Only initially an increased uric acid elimination could be observed. In the further course the uric acid elimination remains increased despite reduced serum concentrations.
口服100毫克苯溴马隆后，在治疗开始至第14天期间，血清尿酸浓度显著降低，平均降至1.7毫克/100毫升；而服用50毫克苯溴马隆仅将尿酸浓度降至3.4毫克/100毫升。因此，差异约为1.7毫克/100毫升。服用100毫克和50毫克苯溴马隆后尿酸排泄均增加。仅在最初可观察到尿酸排泄增加。在后续过程中，尽管血清浓度降低，但尿酸排泄仍保持增加。
