[Effect of benzbromarone in 100mg and 50mg doses on healthy subjects].

After oral application of 100mg of Benzbromarone a significant decrease of the uric acid concentration in the serum up to the 14th day after beginning of the treatment to a mean value of 1,7 mg/100 ml is achieved; while the application of 50 mg of Benzbromarone reduces the uric acid concentration only to a value of 3,4 mg/100 ml. Thereby the differences amounts to about 1,7 mg/100 ml. The urate elimination increases after 100 as well as after 50 mg of Benzbromarone. Only initially an increased uric acid elimination could be observed. In the further course the uric acid elimination remains increased despite reduced serum concentrations.