Däbritz S, Engelhardt W, von Bernuth G, Messmer B J
Department of Thoracic and Cardiovascular Surgery, RWTH Aachen, Germany.
Eur J Cardiothorac Surg. 1997 Jan;11(1):112-6. doi: 10.1016/s1010-7940(96)01065-2.
Arterial switch operation (ASO) is the procedure of choice for the repair of simple d-transposition of the great arteries (TGA) during the neonatal period. Beyond this time such correction is performed in two stages. The first step incorporates banding of the pulmonary artery with or without a Blalock-Taussig shunt to train the left ventricle (LV). The second step consists of the ASO. To find out whether candidates for a two-stage procedure would tolerate a one-stage correction, a trial of pulmonary artery banding was performed.
Between February 1986 and December 1995, 224 patients less than 3 months of age with TGA, intact ventricular septum or a small restrictive ventricular septal defect, had an ASO. Seven patients were 4 weeks of age or older (28-70 days). Two of these had a pulmonary artery to systemic pressure ratio higher than 0.6 and underwent primary ASO without complications. The remaining five patients had low left ventricular pressure with a pulmonary to systemic pressure ratio of 0.2-0.5; echocardiography showed a banana-shaped LV with left ventricular wall thickness as low as 3 mm. They underwent a trial of pulmonary artery banding to systemic pressure for 15-30 min. As this increase in workload was tolerated well with an anticipated decrease of oxygen saturation but without hemodynamic disturbances anticipated, the ASO was performed immediately.
Postoperative course was uneventful in all five patients, although catecholamine dependence was prolonged and three patients received enoximone. There were no severe complications. Echocardiography showed an increase in posterior wall thickness from 3 to 6 mm after 19 days in one infant.
Some of the children, assigned for a 'two-stage' ASO may tolerate a primary anatomic repair up to an age of at least three months. This subgroup can be selected by a trial of pulmonary artery banding.
动脉调转术(ASO)是新生儿期单纯性完全性大动脉转位(TGA)修复的首选术式。超过这个时期,此类矫正需分两期进行。第一步包括在有或无改良布-塔分流术的情况下对肺动脉进行束带术,以训练左心室(LV)。第二步是进行动脉调转术。为了弄清楚两期手术的候选者是否能耐受一期矫正,进行了肺动脉束带试验。
1986年2月至1995年12月期间,224例年龄小于3个月的TGA患儿,室间隔完整或有小型限制性室间隔缺损,接受了动脉调转术。7例患儿年龄为4周或更大(28 - 70天)。其中2例肺动脉与体循环压力比值高于0.6,接受了一期动脉调转术且无并发症。其余5例左心室压力低,肺循环与体循环压力比值为0.2 - 0.5;超声心动图显示左心室呈香蕉形,左心室壁厚度低至3毫米。他们接受了将肺动脉束带至体循环压力15 - 30分钟的试验。由于这种工作量的增加耐受性良好,预期氧饱和度会下降,但无预期的血流动力学紊乱,因此立即进行了动脉调转术。
所有5例患者术后过程均顺利,尽管儿茶酚胺依赖时间延长,3例患者接受了依诺昔酮治疗。无严重并发症。超声心动图显示,1例婴儿在19天后后壁厚度从3毫米增加到6毫米。
一些被安排进行“两期”动脉调转术的儿童可能耐受至少3个月龄的一期解剖修复。这一亚组可通过肺动脉束带试验来选择。