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奎奴普丁/达福普汀在治疗导管相关葡萄球菌感染中潜在作用的体外研究

In vitro study of the potential role of quinupristin/dalfopristin in the treatment of catheter-related staphylococcal infections.

作者信息

Garcia R, Raad I

机构信息

University of Texas M.D. Anderson Cancer Center, Department of Medical Specialties, Houston 77030, USA.

出版信息

Eur J Clin Microbiol Infect Dis. 1996 Dec;15(12):933-6. doi: 10.1007/BF01690511.

DOI:10.1007/BF01690511
PMID:9031876
Abstract

The susceptibility of clinical isolates of methicillin-susceptible and -resistant staphylococci from cancer patients with central venous catheter bacteremia to quinupristin/dalfopristin, a semisynthetic streptogramin, was determined in vitro. Susceptibility of these isolates to nine other antistaphylococcal antibiotics was also determined for comparison. A total of 197 staphylococcal strains were tested from 1983 to 1992. Quinupristin/dalfopristin was bactericidal against all isolates, independent of their resistance to methicillin. Its activity was similar to that of vancomycin but superior to that of teicoplanin. Quinupristin/dalfopristin may prove to be an important addition to our armamentarium against catheter-related staphylococcal infections.

摘要

对癌症患者中心静脉导管菌血症的甲氧西林敏感和耐药葡萄球菌临床分离株，在体外测定了其对一种半合成链阳菌素——奎奴普丁/达福普汀的敏感性。还测定了这些分离株对其他九种抗葡萄球菌抗生素的敏感性以作比较。1983年至1992年共检测了197株葡萄球菌菌株。奎奴普丁/达福普汀对所有分离株均有杀菌作用，与它们对甲氧西林的耐药性无关。其活性与万古霉素相似，但优于替考拉宁。奎奴普丁/达福普汀可能会被证明是我们对抗与导管相关的葡萄球菌感染的药物库中的一种重要补充。

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引用本文的文献

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本文引用的文献

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In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms.注射用链阳性菌素类抗生素RP59500对耐万古霉素革兰氏阳性菌的体外活性
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