Collins L A, Malanoski G J, Eliopoulos G M, Wennersten C B, Ferraro M J, Moellering R C
Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
Antimicrob Agents Chemother. 1993 Mar;37(3):598-601. doi: 10.1128/AAC.37.3.598.
The in vitro activity of RP59500, a streptogramin antibiotic, against 146 clinical isolates of vancomycin-resistant gram-positive bacteria was examined. Five strains of the species Enterococcus casseliflavus and Enterococcus gallinarum, for which the MIC of vancomycin was 8 micrograms/ml, were also studied. Twenty-eight vancomycin-susceptible strains of Enterococcus faecalis and Enterococcus faecium were included for comparison. The drug was highly active against Leuconostoc spp., Lactobacillus spp., and Pediococcus spp. (MICs, < or = 2 micrograms/ml). RP59500 was more active against vancomycin-susceptible strains of E. faecium than E. faecalis (MICs for 90% of the strains [MIC90s], 1.0 versus 32 micrograms/ml). Vancomycin-resistant strains of E. faecalis were as resistant to RP59500 as vancomycin-susceptible strains (MIC90, 32 micrograms/ml), but some vancomycin-resistant E. faecium strains were relatively more resistant to the new agent (MIC90, 16; MIC range, 0.5 to 32 micrograms/ml) than were vancomycin-susceptible organisms of this species.
对链阳性菌素抗生素RP59500针对146株耐万古霉素革兰氏阳性菌临床分离株的体外活性进行了检测。还研究了5株卡西链肠球菌和鹑鸡肠球菌，其万古霉素MIC为8微克/毫升。纳入了28株对万古霉素敏感的粪肠球菌和屎肠球菌菌株作为对照。该药物对明串珠菌属、乳杆菌属和片球菌属具有高度活性（MICs，≤2微克/毫升）。RP59500对万古霉素敏感的屎肠球菌菌株比对粪肠球菌菌株活性更强（90%菌株的MIC[MIC90s]，分别为1.0和32微克/毫升）。耐万古霉素的粪肠球菌菌株对RP59500的耐药性与万古霉素敏感菌株相同（MIC90，32微克/毫升），但一些耐万古霉素的屎肠球菌菌株对这种新药物的耐药性相对比该菌种的万古霉素敏感菌更强（MIC90，16；MIC范围，0.5至32微克/毫升）。
