Baiocchi P, Galiè M, Santini C, Carfagna P, Cassone M, Tarasi D, Venditti M
Department of Clinical Medicine, University of Rome La Sapienza, Italy.
J Chemother. 1998 Feb;10(1):25-8. doi: 10.1179/joc.1998.10.1.25.
Changes in antibiotic susceptibility was evaluated in 77 consecutive nosocomial clinical isolates of Staphylococcus aureus collected from 1986 to 1994 at the Umberto I Polyclinic of the University of Rome (63 isolates) and from 7 other Roman hospitals (14 isolates). Oxacillin resistance in these isolates increased from 39% during the 1980s to 69% during the 1990s. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin were observed among oxacillin-resistant strains. No resistance to glycopeptides was observed although both teicoplanin and vancomycin had slightly reduced antistaphylococcal activity.
对1986年至1994年期间从罗马大学翁贝托一世综合医院收集的77株金黄色葡萄球菌医院临床分离株（63株）以及其他7家罗马医院（14株）的抗生素敏感性变化进行了评估。这些分离株对苯唑西林的耐药性从20世纪80年代的39%增至20世纪90年代的69%。在耐苯唑西林菌株中，观察到对环丙沙星、克林霉素和利福平的耐药性显著增加。尽管替考拉宁和万古霉素的抗葡萄球菌活性略有降低，但未观察到对糖肽类的耐药性。
