Phosphorylation destabilizes alpha-helices. - Suppr | 超能文献

文献检索
文档翻译
深度研究
学术资讯

Zotero 插件

邀请有礼
套餐&价格
历史记录

应用&插件

Zotero 插件浏览器插件 Mac 客户端 Windows 客户端微信小程序

定价

高级版会员购买积分包购买API积分包

服务

文献检索文档翻译深度研究 API 文档 MCP 服务

关于我们

关于 Suppr 公司介绍联系我们用户协议隐私条款

关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Phosphorylation destabilizes alpha-helices. - Suppr | 超能文献

Phosphorylation destabilizes alpha-helices.

作者信息

Szilák L, Moitra J, Krylov D, Vinson C

出版信息

Nat Struct Biol. 1997 Feb;4(2):112-4. doi: 10.1038/nsb0297-112.

DOI:10.1038/nsb0297-112

Abstract

Phosphorylation of threonine destabilizes the leucine zipper of a bZIP protein by 4.6 kcal mol-1 dimer-1, which reduces DNA binding 100-fold. This decrease in stability reflects the low alpha-helix forming propensity of a phosphorylated threonine.

摘要

相似文献

1

Phosphorylation destabilizes alpha-helices.

Nat Struct Biol. 1997 Feb;4(2):112-4. doi: 10.1038/nsb0297-112.

2

Design of a leucine zipper coiled coil stabilized 1.4 kcal mol-1 by phosphorylation of a serine in the e position.通过对ε位丝氨酸进行磷酸化使亮氨酸拉链卷曲螺旋稳定化，稳定化程度为1.4千卡/摩尔。

Protein Sci. 1997 Jun;6(6):1273-83. doi: 10.1002/pro.5560060615.

3

A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions.用于亮氨酸拉链稳定性和二聚化特异性的热力学标度：e和g螺旋间相互作用

EMBO J. 1994 Jun 15;13(12):2849-61. doi: 10.1002/j.1460-2075.1994.tb06579.x.

4

Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc.致癌转录因子v-Myc二聚化及DNA结合结构域的结构、功能与动力学

J Mol Biol. 2001 Apr 13;307(5):1395-410. doi: 10.1006/jmbi.2001.4537.

5

Extending dimerization interfaces: the bZIP basic region can form a coiled coil.扩展二聚化界面：bZIP碱性区域可形成卷曲螺旋。

EMBO J. 1995 Nov 1;14(21):5329-37. doi: 10.1002/j.1460-2075.1995.tb00217.x.

6

The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.完整的人类Max-DNA复合物的晶体结构：转录控制机制的新见解。

Structure. 1997 Apr 15;5(4):509-20. doi: 10.1016/s0969-2126(97)00207-4.

7

Certain bZIP peptides bind DNA sequentially as monomers and dimerize on the DNA.某些碱性亮氨酸拉链（bZIP）肽作为单体依次结合DNA，并在DNA上二聚化。

Nat Struct Biol. 1997 Feb;4(2):115-7. doi: 10.1038/nsb0297-115.

8

The bZIP region of the plant transcription factor opaque-2 forms stable homodimers in solution and retains its helical structure upon subunit dissociation.植物转录因子不透明2的碱性亮氨酸拉链（bZIP）区域在溶液中形成稳定的同型二聚体，并且在亚基解离后保持其螺旋结构。

Biochemistry. 2004 Apr 27;43(16):4862-8. doi: 10.1021/bi035905e.

9

Preferential heterodimeric parallel coiled-coil formation by synthetic Max and c-Myc leucine zippers: a description of putative electrostatic interactions responsible for the specificity of heterodimerization.合成的Max和c-Myc亮氨酸拉链优先形成异源二聚体平行卷曲螺旋：对负责异源二聚化特异性的假定静电相互作用的描述。

J Mol Biol. 1995 Dec 1;254(3):505-20. doi: 10.1006/jmbi.1995.0634.

10

Monomeric and dimeric bZIP transcription factor GCN4 bind at the same rate to their target DNA site.单体和二聚体碱性亮氨酸拉链转录因子GCN4以相同速率与其靶DNA位点结合。

Biochemistry. 2004 Jan 27;43(3):718-27. doi: 10.1021/bi0355793.

引用本文的文献

1

Rational Design of Phosphorylation-Responsive Coiled Coil-Peptide Assemblies.磷酸化响应性螺旋-肽组装体的合理设计。

ACS Synth Biol. 2023 Apr 21;12(4):1308-1319. doi: 10.1021/acssynbio.3c00064. Epub 2023 Mar 29.

2

A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection.WRN 的非催化 N 端结构域防止有丝分裂中端粒去保护。

Sci Rep. 2023 Jan 12;13(1):645. doi: 10.1038/s41598-023-27598-0.

3

α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif.

通过在碱性激酶-底物基序中协同侧链电荷强化相互作用稳定 α-螺旋与磷酸丝氨酸的结合。

Biochem J. 2022 Mar 18;479(5):687-700. doi: 10.1042/BCJ20210812.

4

De novo design of a reversible phosphorylation-dependent switch for membrane targeting.从头设计一个可逆磷酸化依赖的膜靶向开关。

Nat Commun. 2021 Mar 5;12(1):1472. doi: 10.1038/s41467-021-21622-5.

5

Self-assembly of the bZIP transcription factor ΔFosB.碱性亮氨酸拉链转录因子ΔFosB的自组装

Curr Res Struct Biol. 2020;2:1-13. doi: 10.1016/j.crstbi.2019.12.001. Epub 2019 Dec 24.

6

Structural preferences of cysteine sulfinic acid: The sulfinate engages in multiple local interactions with the peptide backbone.半胱氨酸亚磺酸的结构偏好：亚磺酸盐与肽骨架发生多种局部相互作用。

Free Radic Biol Med. 2020 Feb 20;148:96-107. doi: 10.1016/j.freeradbiomed.2019.12.030. Epub 2019 Dec 26.

7

Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α.Ran 途径非依赖性调控有丝分裂期高尔基复合体的解体通过 Importin-α。

Nat Commun. 2019 Sep 20;10(1):4307. doi: 10.1038/s41467-019-12207-4.

8

Phosphorylation-dependent protein design: design of a minimal protein kinase-inducible domain.磷酸化依赖的蛋白质设计：最小蛋白激酶诱导结构域的设计。

Org Biomol Chem. 2019 Apr 17;17(16):3984-3995. doi: 10.1039/c9ob00502a.

9

Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.鸡 CREB3 bZIP 晶体结构的研究结果表明，CREB3 亚家族转录因子成员可能会对氧化应激产生反应而被激活。

Protein Sci. 2019 Apr;28(4):779-787. doi: 10.1002/pro.3573. Epub 2019 Feb 6.

10

Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.两种丝虫脂肪酸和视黄醇（FAR）结合蛋白的配体结合特性及其在沙鼠挑战感染中的疫苗效果。

PLoS Negl Trop Dis. 2018 Oct 8;12(10):e0006772. doi: 10.1371/journal.pntd.0006772. eCollection 2018 Oct.