Bernière J, Gerota I
Département Anesthésiologie, Hôpital Trousseau, Paris.
Cah Anesthesiol. 1996;44(4):303-8.
The usual methods like hypotension, isovolaemic haemodilution, autologous transfusion and peri-operative blood salvage may significantly reduce the need for homologous blood transfusion in haemorrhagic surgery and also the risk of transmitting infectious agents. Erythropoietin (EPO) is now available and is used to stimulate red cell regeneration in pre-operative autologous blood donation. In acute anaemia, many studies have shown that the stimulation of endogenous erythropoietin production could be very high and accelerate red blood cell production. Taking higher quantities of blood than usual induces a secretion of endogenous erythropoietin, and could be an alternative for the utilization of exogenous EPO in autologous blood donation.
诸如低血压、等容性血液稀释、自体输血和围手术期血液回收等常用方法，可显著减少出血性手术中对异体输血的需求，同时降低传播感染因子的风险。促红细胞生成素（EPO）现已可用，并用于术前自体献血中刺激红细胞再生。在急性贫血中，许多研究表明，内源性促红细胞生成素的分泌可非常高，并加速红细胞生成。采集比平常更多的血液可诱导内源性促红细胞生成素的分泌，这可能是在自体献血中替代使用外源性EPO的一种方法。
