Dowaki Y, Sakata N, Saigo K, Ryo R, Mizuno K
Hyogo Red Cross Blood Center, Kobe.
Rinsho Byori. 1997 Jan;45(1):72-6.
Autologous blood transfusion is advantageous in that it eliminates the risk of transfusion-transmitted infection or complications caused by the immune reaction. Increased platelet counts after repeated phlebotomy are commonly observed. This study was carried out to clarify the mechanism of increased platelets during preoperative autologous blood donation. Eleven patients of elective surgery in which is in good preoperative condition and there is no emergency were selected for this study. Blood cell counts, platelet size distribution(PDW, MPV, P-LCR) and serum concentration of erythropoietin(EPO), interleukin-3(IL-3) and interleukin-6(IL-6)were measured. A transient increase in platelet was seen in almost patients during preoperative autologous blood donation. No marked changes in platelet size distribution and serum concentration of EPO, IL-3 and IL-6. These results suggest that increased platelet counts during preoperative autologous blood donation might be caused by some specific cytokines related to megakaryocyte differentiation such as c-MPL ligand.
自体输血的优势在于它消除了输血传播感染或免疫反应引起的并发症的风险。反复静脉放血后血小板计数增加是常见现象。本研究旨在阐明术前自体献血期间血小板增加的机制。本研究选取了11例择期手术患者，这些患者术前状况良好且无急诊情况。测量了血细胞计数、血小板大小分布（血小板分布宽度、平均血小板体积、血小板大型比率）以及促红细胞生成素（EPO）、白细胞介素-3（IL-3）和白细胞介素-6（IL-6）的血清浓度。在几乎所有患者的术前自体献血期间都观察到血小板短暂增加。血小板大小分布以及EPO、IL-3和IL-6的血清浓度没有明显变化。这些结果表明，术前自体献血期间血小板计数增加可能是由一些与巨核细胞分化相关的特定细胞因子引起的，如c-MPL配体。
