Williams N M, Jones L A, Murphy K C, Cardno A G, Asherson P, Williams J, McGuffin P, Owen M J
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Am J Med Genet. 1997 Feb 21;74(1):37-9. doi: 10.1002/(sici)1096-8628(19970221)74:1<37::aid-ajmg8>3.0.co;2-s.
We report a case control association study using markers D22S278 and D22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 controls matched for ethnicity, age and sex. No differences between allele frequencies for either marker were observed when the two groups were compared (D22S278: chi 2 = 6.53, df = 7, P = 0.51; D22S283: chi 2 = 14.73, df = 15, P = 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia.
我们报告了一项病例对照关联研究，该研究使用标记物D22S278和D22S283，纳入了90名患有DSMIII-R精神分裂症的无血缘关系患者以及90名在种族、年龄和性别上匹配的对照。比较两组时，未观察到任一标记物的等位基因频率存在差异（D22S278：卡方 = 6.53，自由度 = 7，P = 0.51；D22S283：卡方 = 14.73，自由度 = 15，P = 0.48）。这些发现不支持其他人之前的研究工作，即认为标记物D22S278和D22S283与精神分裂症之间存在等位基因关联。
