Villar H E, Laurino G, Hoffman M
Laboratorio de Bacteriología, Hospital Enrique Tornu, Buenos Aires, Argentina.
Enferm Infecc Microbiol Clin. 1996 Nov;14(9):524-7.
To evaluate the bactericidal activity of colistin, imipenem and sulbactam against 24 Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolations.
Bactericidal activity was estimated by using killing curves method. The concentrations employed were: colistin 4 mg/l, imipenem 8 mg/l and sulbactam 8 and 32 mg/l.
Colistin was bactericidal in 24 isolations after 6 hours of incubation. When we used 8 mg/l of imipenem we detected bactericidal activity at the susceptible strains (MIC < or = 4 mg/l). We found bactericidal effect in 15 of 18 strains susceptible to sulbactam when we used 8 mg/l in killing curves after 24 hours of incubation. Using 32 mg/l we detected the same effect in 18 strains with MIC < or = 8 mg/l.
Considering the high incidence of resistance in Acinetobacter spp. to several antibiotics including imipenem, we consider that sulbactam could be an excellent therapeutic alternative because it presents bactericidal activity in susceptible strains.
评估黏菌素、亚胺培南和舒巴坦对24株醋酸钙不动杆菌-鲍曼不动杆菌复合体分离株的杀菌活性。
采用杀菌曲线法评估杀菌活性。使用的浓度为：黏菌素4mg/l、亚胺培南8mg/l以及舒巴坦8mg/l和32mg/l。
孵育6小时后，黏菌素对24株分离株具有杀菌作用。当使用8mg/l亚胺培南时，在敏感菌株（MIC≤4mg/l）中检测到杀菌活性。在孵育24小时后的杀菌曲线中，当使用8mg/l舒巴坦时，在18株对舒巴坦敏感的菌株中有15株发现有杀菌作用。使用32mg/l时，在18株MIC≤8mg/l的菌株中检测到相同效果。
考虑到不动杆菌属对包括亚胺培南在内的多种抗生素耐药率较高，我们认为舒巴坦可能是一种很好的治疗选择，因为它在敏感菌株中具有杀菌活性。
