Volm M, Koomägi R, Mattern J
German Cancer Research Center, Department of Oncological Diagnostics and Therapy, Heidelberg, Germany.
Int J Cancer. 1997 Feb 20;74(1):64-8. doi: 10.1002/(sici)1097-0215(19970220)74:1<64::aid-ijc11>3.0.co;2-i.
Tumor specimens from 109 patients with previously untreated squamous cell lung carcinomas were analyzed immunohistologically for the expression of vascular endothelial growth factor (VEGF) and its receptor Flt-1. Our analysis attempted to determine whether these factors have additional prognostic value for the patients' survival. VEGF staining was seen in 59% and Flt-1 staining in 68% of the cases. No significant correlations were detected between VEGF or Flt-1 expression and stage or metastasis. Patients with VEGF-stained tumors had significantly lower survival times than patients with negative tumors. Expression of Flt-1 showed no significant correlation with survival. Combining VEGF and Flt-1 expressions did not improve the prognostic value. Multivariate analysis showed that metastasis and VEGF expression are significant and independent prognostic factors for the survival of patients with squamous cell lung carcinomas.
对109例先前未经治疗的肺鳞状细胞癌患者的肿瘤标本进行免疫组织学分析，以检测血管内皮生长因子（VEGF）及其受体Flt-1的表达。我们的分析试图确定这些因素对患者生存是否具有额外的预后价值。59%的病例可见VEGF染色，68%的病例可见Flt-1染色。未检测到VEGF或Flt-1表达与分期或转移之间存在显著相关性。VEGF染色阳性肿瘤患者的生存时间显著低于阴性肿瘤患者。Flt-1的表达与生存无显著相关性。联合VEGF和Flt-1表达并未提高预后价值。多变量分析显示，转移和VEGF表达是肺鳞状细胞癌患者生存的显著且独立的预后因素。
