Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, 266000, Shandong, China.
Department of Blood Transfusion, The Central Hospital of Qingdao Jiaozhou, 99 Yunxi River South Road, Qingdao, 266300, Shandong, China.
J Transl Med. 2024 Apr 18;22(1):371. doi: 10.1186/s12967-024-05126-6.
Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby promoting their colonization and metastasis to distant organs. Platelets can affect the tumor microenvironment via interactions between platelet-related factors and tumor cells. Metastasis is a key event in cancer-related death and is associated with platelet-related factors in lung, breast, and colorectal cancers. Although the factors that promote platelet expression vary slightly in terms of their type and mode of action, they all contribute to the overall process. Recognizing the correlation and mechanisms between these factors is crucial for studying the colonization of distant target organs and developing targeted therapies for these three types of tumors. This paper reviews studies on major platelet-related factors closely associated with metastasis in lung, breast, and colorectal cancers.
血小板不仅参与血栓形成和止血，还与肿瘤细胞相互作用，保护其免受血流切应力和自然杀伤细胞溶解造成的机械损伤，从而促进肿瘤细胞在远处器官的定植和转移。血小板可以通过血小板相关因子与肿瘤细胞的相互作用来影响肿瘤微环境。转移是癌症相关死亡的关键事件，与肺癌、乳腺癌和结直肠癌中的血小板相关因子有关。尽管促进血小板表达的因素在类型和作用方式上略有不同，但它们都有助于整体过程。认识这些因素之间的相关性和机制对于研究远处靶器官的定植以及开发这三种肿瘤的靶向治疗至关重要。本文综述了与肺癌、乳腺癌和结直肠癌转移密切相关的主要血小板相关因子的研究进展。
