Cerbo R, Barbanti P, Buzzi M G, Fabbrini G, Brusa L, Roberti C, Zanette E, Lenzi G L
Department of Neurological Sciences, University La Sapienza, Rome, Italy.
Clin Neuropharmacol. 1997 Feb;20(1):36-41. doi: 10.1097/00002826-199702000-00004.
We investigated the effects of apomorphine administration at two different doses (2-10 micrograms/kg, s.c.) in 35 migraineurs in headache-free period and in 20 age-matched healthy control subjects, with and without pretreatment with domperidone. Neither patients or controls complained of headache at either dose, whereas at the dose of 10 micrograms/kg migraineurs showed a statistically significant higher incidence of dopaminergic symptoms (nausea, vomiting, drowsiness, yawning, dizziness, sweating) than controls. Furthermore, symptoms due to postsynaptic dopamine receptors activation (i.e., nausea and vomiting) only appeared in migraineurs. No symptom, however, resembled those characterizing a spontaneous migraine attack. In conclusion, migraineurs show a lower threshold for dopamine receptor activation than normal subjects.
我们研究了皮下注射两种不同剂量（2 - 10微克/千克）阿扑吗啡对35名处于无头痛期的偏头痛患者以及20名年龄匹配的健康对照者的影响，其中部分受试者接受了多潘立酮预处理，部分未接受。无论是患者还是对照者，在两种剂量下均未主诉头痛，然而，在10微克/千克剂量时，偏头痛患者出现多巴胺能症状（恶心、呕吐、嗜睡、打哈欠、头晕、出汗）的发生率在统计学上显著高于对照者。此外，由于突触后多巴胺受体激活引起的症状（即恶心和呕吐）仅出现在偏头痛患者中。然而，没有任何症状类似于自发性偏头痛发作的特征。总之，偏头痛患者比正常受试者对多巴胺受体激活的阈值更低。
