Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Regional Referral Headache Centre, S.S. Filippo e Nicola Hospital, Avezzano, L'Aquila, Italy.
J Headache Pain. 2020 Oct 27;21(1):126. doi: 10.1186/s10194-020-01192-5.
Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Recent biochemical and functional imaging studies identified central nervous system structures and neurotransmitters involved in the pathophysiology of migraine and also important for the regulation of normal sleep architecture, suggesting a possible causative role, in the pathogenesis of both disorders, of a dysregulation in these common nervous system pathways.This systematic review summarizes the existing data on migraine and sleep disorders with the aim to evaluate the existence of a causal relationship and to assess the presence of influencing factors. The identification of specific sleep disorders associated with migraine should induce clinicians to systematically assess their presence in migraine patients and to adopt combined treatment strategies.
偏头痛和睡眠障碍是常见且常令人困扰的慢性疾病，在普通人群中的发病率很高，并且会造成相当大的社会经济影响和负担。临床医生和流行病学研究几个世纪以来已经认识到偏头痛和睡眠障碍之间存在关系。然而，这种关联的确切性质、潜在机制和相互作用很复杂，尚未完全了解。最近的生化和功能影像学研究确定了中枢神经系统结构和神经递质，它们参与偏头痛的病理生理学，对于正常睡眠结构的调节也很重要，这表明在这两种疾病的发病机制中，这些常见的神经系统通路的失调可能起着因果作用。本系统综述总结了偏头痛和睡眠障碍的现有数据，旨在评估因果关系的存在，并评估影响因素的存在。确定与偏头痛相关的特定睡眠障碍，应促使临床医生系统地评估偏头痛患者中这些障碍的存在，并采取联合治疗策略。
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