运动神经元病中的碳水化合物代谢
Carbohydrate metabolism in motor neurone disease.
作者信息
Saffer D, Morley J, Bill P L
出版信息
J Neurol Neurosurg Psychiatry. 1977 Jun;40(6):533-7. doi: 10.1136/jnnp.40.6.533.
Eight patients with classical motor neurone disease, and eight control patients with neurological disease and matched for degree of wasting, were studied. Both groups had abnormal glucose tolerance, but the patients with motor neurone disease had a significantly lower insulin response both to oral glucose loading and to intravenous tolbutamide. These results suggest that in patients with motor neurone disease there is an impaired synthesis or release of insulin due to islet cell damage. Blood pyruvate and lactate, and cerebrospinal fluid pyruvate, lactate, and citrate, did not differ significantly from the control group. Blood citrate levels were significantly higher in patients with motor neurone disease compared with the controls. Triglyceride levels were raised in patients with motor neurone disease compared to the control patients. This may be secondary to the increased citrate levels.
对8例患有典型运动神经元病的患者以及8例患有神经系统疾病且消瘦程度相匹配的对照患者进行了研究。两组患者的葡萄糖耐量均异常，但运动神经元病患者对口服葡萄糖负荷和静脉注射甲苯磺丁脲的胰岛素反应均显著降低。这些结果表明，运动神经元病患者由于胰岛细胞损伤，胰岛素合成或释放受损。血液丙酮酸和乳酸以及脑脊液丙酮酸、乳酸和柠檬酸与对照组相比无显著差异。运动神经元病患者的血液柠檬酸水平与对照组相比显著更高。与对照患者相比，运动神经元病患者的甘油三酯水平升高。这可能继发于柠檬酸水平的升高。
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